Introduction to the membrane protein reviews: The interplay of structure, dynamics, and environment in membrane protein function

被引:82
作者
Sachs, Jonathan N. [1 ]
Engelman, Donald M. [1 ]
机构
[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA
关键词
D O I
10.1146/annurev.biochem.75.110105.142336
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
we introduce an organizational scheme for membrane In our review, protein function. It is the relationship between structure, dynamics, and environment that endows the membrane and its constituents with remarkable sensitivity and robustness. Our understanding begins with landmark advances like those presented in the following chapters. Membrane proteins are notoriously difficult to study, and so the work presented here on the ADP/ATP carrier [Nury et al. (2)], rhodopsin [Palczewski (24)], and the cytochrome b(6)f complex [Cramer et al. (3 5)] represents incredible progress in this now blossoming field.
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页码:707 / 712
页数:6
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