The Regional Sensitivity of Chondrocyte Gene Expression to Coactive Mechanical Load and Exogenous TNF-α Stimuli

被引：15

作者：

Bevill, S. L. ^{[1
]}

Boyer, K. A. ^{[2
]}

Andriacchi, T. P. ^{[3
,4
,5
]}

机构：

[1] Colorado Mesa Univ, Dept Phys & Environm Sci, Grand Junction, CO 81501 USA

[2] Univ Massachusetts, Dept Kinesiol, Amherst, MA 01003 USA

[3] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Orthoped Surg, Med Ctr, Stanford, CA 94305 USA

[5] Bone & Joint Ctr Excellence, Palo Alto, CA USA

来源：

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 2014年 / 136卷 / 09期

基金：

美国国家卫生研究院;

关键词：

ANTERIOR CRUCIATE LIGAMENT; TUMOR-NECROSIS-FACTOR; HUMAN ARTICULAR-CARTILAGE; IN-VIVO; INFLAMMATORY CYTOKINES; STATIC COMPRESSION; TISSUE INHIBITOR; DEFICIENT KNEE; OSTEOARTHRITIS; INTERLEUKIN-1;

D O I：

10.1115/1.4027937

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

Both mechanical load and elevated levels of proinflammatory cytokines have been associated with the risk for developing osteoarthritis (OA), yet the potential interaction of these mechanical and biological factors is not well understood. The purpose of this study was to evaluate the response of chondrocytes to the effects of dynamic unconfined compression, TNF-alpha, and the simultaneous effects of dynamic unconfined compression and TNF-alpha. The response to these three treatments was markedly different and, taken together, the response in the gene expression of chondrocytes to the different treatment conditions suggest a complex interaction between structure, biology, and mechanical loading.

引用

页数：7

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