Actin-binding protein filamin A is displayed on the surface of human neuroblastoma cells

被引：21

作者：

Bachmann, Andre S. ^{[1
]}

Howard, James P. ^{[1
]}

Vogel, Carl-Wilhelm ^{[1
]}

机构：

[1] Univ Hawaii Manoa, Canc Res Ctr Hawaii, Honolulu, HI 96813 USA

来源：

CANCER SCIENCE | 2006年 / 97卷 / 12期

关键词：

D O I：

10.1111/j.1349-7006.2006.00327.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We previously reported the identification of natural human IgM antibodies, which recognize a M-r 260 000 surface protein (NB-p260) and induce both complement-mediated cytotoxicity and apoptosis of human neuroblastoma cells. NB-p260 was shown to belong to the family of filamin proteins. Filamin A is a high molecular weight actin-binding protein, previously thought to be only located intracellularly. Here we show that NB cells as well as three NB-unrelated human cell lines express filamin A also on the cell surface. Our findings suggest new biological functions for filamins, including a role as mediators in anti-NB IgM-induced apoptosis, and they add to the growing body of evidence of the interaction of cytoskeletal proteins with the extracellular matrix.

引用

页码：1359 / 1365

页数：7

共 41 条

[1]

ADAM A, 1981, CANCER, V47, P373, DOI 10.1002/1097-0142(19810115)47:2<373::AID-CNCR2820470227>3.0.CO

[2]

2-O

[3]

BACHMANN AS, 2002, P C ADV NEUR RES 17

[4] FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin a-mediated manner [J].

Berry, FB ;

O'Neill, MA ;

Coca-Prados, M ;

Walter, MA .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (04) :1415-1424

[5] Mutations in FLNB cause boomerang dysplasia -: art. no. e43 [J].

Bicknell, LS ;

Morgan, T ;

Bonafé, L ;

Wessels, MW ;

Bialer, MG ;

Willems, PJ ;

Cohn, DH ;

Krakow, D ;

Robertson, SP .

JOURNAL OF MEDICAL GENETICS, 2005, 42 (07)

[6]

Bolande R P, 1991, Pathol Annu, V26 Pt 2, P187

[7] THE CYTOLYSIS OF HUMAN NEUROBLASTOMA-CELLS BY A NATURAL IGM ANTIBODY-COMPLEMENT SYSTEM IN PREGNANCY SERUM [J].

BOLANDE, RP ;

MAYER, DC .

CANCER INVESTIGATION, 1990, 8 (06) :603-611

[8] Neuroblastoma: Biological insights into a clinical enigma [J].

Brodeur, GM .

NATURE REVIEWS CANCER, 2003, 3 (03) :203-216

[9] Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family [J].

Chakarova, C ;

Wehnert, MS ;

Uhl, K ;

Sakthivel, S ;

Vosberg, HP ;

van der Ven, PFM ;

Fürst, DO .

HUMAN GENETICS, 2000, 107 (06) :597-611

[10] Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: the dense alignment surface method [J].

Cserzo, M ;

Wallin, E ;

Simon, I ;

vonHeijne, G ;

Elofsson, A .

PROTEIN ENGINEERING, 1997, 10 (06) :673-676

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