The ced-8 gene controls the timing of programmed cell deaths in C. elegans

被引:95
作者
Stanfield, GM [1 ]
Horvitz, HR [1 ]
机构
[1] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA
关键词
D O I
10.1016/S1097-2765(00)80437-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Loss-of-function mutations in the gene ced-8 lead to the late appearance of cell corpses during embryonic development in C. elegans. ced-8 functions downstream of or in parallel to the regulatory cell death gene ced-9 and may function as a cell death effector downstream of the caspase encoded by the programmed cell death killer gene ced-3. In ced-8 mutants, embryonic programmed cell death probably initiates normally but proceeds slowly, ced-8 encodes a transmembrane protein that appears to be localized to the plasma membrane. The CED-8 protein is similar to human XK, a putative membrane transport protein implicated in McLeod Syndrome, a form of hereditary neuroacanthocytosis.
引用
收藏
页码:423 / 433
页数:11
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