SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp II.: Structure determination

被引：23

作者：

Houge-Frydrych, CSV ^{[1
]}

Readshaw, SA ^{[1
]}

Bell, DJ ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 04期

关键词：

D O I：

10.7164/antibiotics.53.351

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel tyrosyl tRNA synthetase inhibitor, SB-219383, has been isolated from a Micromonospora sp. The structure of SE-219383 has been elucidated by a combination of derivatisation, spectroscopic and other analytical techniques and found to be N-(L-tyrosyl)-2amino[1(S*),3(S*),4(S*),5(R*),8(R*)-2,4,5,8-tetrahydroxy-7-oxa-2-azabicyclo[3.2.1]oct-3-yl]acetic acid (1).

引用

页码：351 / 356

页数：6

共 6 条

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[2]

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[6] SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp I.: Fermentation, isolation and properties [J].

Stefanska, AL ;

Coates, NJ ;

Mensah, LM ;

Pope, AJ ;

Ready, SJ ;

Warr, SR .

JOURNAL OF ANTIBIOTICS, 2000, 53 (04) :345-350

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