Exomics and immunogenics Bridging mutational load and immune checkpoints efficacy

被引：163

作者：

Champiat, Stephane ^{[1
]}

Ferte, Charles ^{[2
,3
]}

Lebel-Binay, Sophie ^{[4
]}

Eggermont, Alexander ^{[5
]}

Soria, Jean-Charles ^{[1
,3
,4
,6
]}

机构：

[1] Univ Paris Sud, DITEP, Villejuif, France

[2] Univ Paris Sud, Dept Med Oncol, Villejuif, France

[3] Univ Paris Sud, INSERM U981, Villejuif, France

[4] Univ Paris Sud, SIRIC SOCRATE, Villejuif, France

[5] Univ Paris Sud, Villejuif, France

[6] Univ Paris Sud, Thorac Multidisciplinary Committee, Villejuif, France

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期

关键词：

immune checkpoints; immunotherapy; mutational heterogeneity; PD-1; PD-L1; T-CELL RESPONSES; PARALLEL DETECTION; CANCER GENOME; LUNG-CANCER; ANTIBODY; SAFETY; SIGNATURES; ANTI-PD-1;

D O I：

10.4161/onci.27817

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anti-PD-1/PD-L1 antibodies are emerging as promising anticancer therapeutics. Interestingly, elevated response rates to these agents are mostly documented among patients with tumors that bear high level of somatic mutations, like melanoma or non-small cell lung carcinoma. We herein formulate the hypothesis that high levels of mutational heterogeneity in the tumor could be the key for the success of immune checkpoint-targeting therapies.

引用

页数：6

共 25 条

[1] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[2] Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers [J].

Andersen, Rikke Sick ;

Kvistborg, Pia ;

Frosig, Thomas Morch ;

Pedersen, Natasja W. ;

Lyngaa, Rikke ;

Bakker, Arnold H. ;

Shu, Chengyi Jenny ;

Straten, Per Thor ;

Schumacher, Ton N. ;

Hadrup, Sine Reker .

NATURE PROTOCOLS, 2012, 7 (05) :891-902

[3]

[Anonymous], J CLIN ONCOL

[4] Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer [J].

Brahmer, Julie R. ;

Tykodi, Scott S. ;

Chow, Laura Q. M. ;

Hwu, Wen-Jen ;

Topalian, Suzanne L. ;

Hwu, Patrick ;

Drake, Charles G. ;

Camacho, Luis H. ;

Kauh, John ;

Odunsi, Kunle ;

Pitot, Henry C. ;

Hamid, Omid ;

Bhatia, Shailender ;

Martins, Renato ;

Eaton, Keith ;

Chen, Shuming ;

Salay, Theresa M. ;

Alaparthy, Suresh ;

Grosso, Joseph F. ;

Korman, Alan J. ;

Parker, Susan M. ;

Agrawal, Shruti ;

Goldberg, Stacie M. ;

Pardoll, Drew M. ;

Gupta, Ashok ;

Wigginton, Jon M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) :2455-2465

[5] Translating Tumor Antigens into Cancer Vaccines [J].

Buonaguro, Luigi ;

Petrizzo, Annacarmen ;

Tornesello, Maria Lina ;

Buonaguro, Franco M. .

CLINICAL AND VACCINE IMMUNOLOGY, 2011, 18 (01) :23-34

[6] Exploiting the Mutanome for Tumor Vaccination [J].

Castle, John C. ;

Kreiter, Sebastian ;

Diekmann, Jan ;

Loewer, Martin ;

Van de Roemer, Niels ;

de Graaf, Jos ;

Selmi, Abderraouf ;

Diken, Mustafa ;

Boegel, Sebastian ;

Paret, Claudia ;

Koslowski, Michael ;

Kuhn, Andreas N. ;

Britten, Cedrik M. ;

Huber, Christoph ;

Tuereci, Oezlem ;

Sahin, Ugur .

CANCER RESEARCH, 2012, 72 (05) :1081-1091

[7] Argo-China PREFACE [J].

Chen, Dake .

ATMOSPHERE-OCEAN, 2012, 50 :1-1

[8]

Cho D.C., 2013, J. Clin. Oncol, V31, P15, DOI [10.1200/jco.2013.31.15_suppl.4505, DOI 10.1200/JCO.2013.31.15_SUPPL.4505]

[9] Inflammation and immune surveillance in cancer [J].

Chow, Melvyn T. ;

Moeller, Andreas ;

Smyth, Mark J. .

SEMINARS IN CANCER BIOLOGY, 2012, 22 (01) :23-32

[10] "Hard" and "soft" lesions underlying the HLA Class I alterations in cancer cells: implications for immunotherapy [J].

Garrido, Federico ;

Cabrera, Teresa ;

Aptsiauri, Natalia .

INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (02) :249-256

← 1 2 3 →