GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats

被引：46

作者：

Edwards, JE

Brouwer, KR

McNamara, PJ

机构：

[1] Univ Kentucky, Coll Pharm, Grad Ctr Toxicol, Lexington, KY 40536 USA

[2] Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40536 USA

[3] Glaxo Wellcome Inc, Bioanal & Drug Metab, Res Triangle Pk, NC 27709 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 07期

关键词：

D O I：

10.1128/AAC.46.7.2284-2286.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The goal of this study was to determine the distribution of unbound amprenavir in the central nervous system (CNS) of rats. The concentration of unbound amprenavir in the extracellular fluid of the brain and the blood was examined in the presence and absence of the MDR modulator GF120918 by microdialysis. The brain-to-blood ratio of amprenavir in the absence and presence of GF120918 was found to be significantly different (P < 0.003; 0.076 and 0.617, respectively). The use of the MDR modulator GF120918 could potentially increase the penetration of human immunodeficiency virus protease inhibitors into the CNS.

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页码：2284 / 2286

页数：3

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