Late-Life Body Mass Index and Waist Circumference in Amnestic Mild Cognitive Impairment and Alzheimer's Disease

被引：36

作者：

Chua, Leung-Wing ^{[1
,2
,3
]}

Tam, Sidney ^{[2
,4
]}

Lee, Peter W. H. ^{[5
,6
]}

Yik, Ping-Yiu ^{[1
]}

Song, Youqiang ^{[3
,7
]}

Cheung, Bernard M. Y. ^{[2
,8
,9
]}

Lam, Karen S. L. ^{[2
,3
,10
]}

机构：

[1] Univ Hong Kong, Queen Mary Hosp, Dept Med, Div Geriatr Med,Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Res Ctr Heart Brain Hormone & Healthy Aging, Hong Kong, Hong Kong, Peoples R China

[3] Univ Hong Kong, Alzheimers Dis Res Network, Hong Kong, Hong Kong, Peoples R China

[4] Univ Hong Kong, Queen Mary Hosp, Li Ka Shing Fac Med, Div Clin Biochem, Hong Kong, Hong Kong, Peoples R China

[5] Univ Hong Kong, Queen Mary Hosp, Li Ka Shing Fac Med, Dept Clin Psychol, Hong Kong, Hong Kong, Peoples R China

[6] Univ Hong Kong, Queen Mary Hosp, Li Ka Shing Fac Med, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China

[7] Univ Hong Kong, Dept Biochem, Hong Kong, Hong Kong, Peoples R China

[8] Univ Hong Kong, Queen Mary Hosp, Dept Med, Div Clin Pharmacol,Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China

[9] Univ Birmingham, Dept Clin Pharmacol, Div Med Sci, Birmingham, W Midlands, England

[10] Univ Hong Kong, Queen Mary Hosp, Dept Med, Div Endocrinol & Metab,Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2009年 / 17卷 / 01期

关键词：

Aging; Alzheimer's disease; body mass index; Chinese; mild cognitive impairment; WEIGHT-LOSS; BIOAVAILABLE TESTOSTERONE; PHYSICAL-ACTIVITY; CENTRAL OBESITY; OLDER-PEOPLE; FOLLOW-UP; RISK; DEMENTIA; MORTALITY; POLYMORPHISM;

D O I：

10.3233/JAD-2009-1043

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

We investigated the progressive associations of late-life body mass index (BMI) and waist circumference (WC) with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) in Chinese older adults in a case-control study. Late-life BMI and WC were measured. AD was diagnosed by the NINCDS-ADRDA criteria for probable AD and aMCI by the Petersen's criteria. 426 Chinese older adults [125 AD, 125 aMCI and 176 controls with normal cognition (NC)], aged 55 to 93 years old, were recruited. Both BMI and WC decreased significantly across the normal, aMCI, and AD groups (dementia diagnostic group: p for trend < 0.001 and 0.016 respectively, 1-way ANOVA). After adjustment for significant confounders, multivariate general linear model analyses showed that the dementia diagnostic group (AD/aMCI/NC) was a significant independent predictor of both the late-life BMI and late-life WC(p = 0.002 and 0.018 respectively). In conclusion, late-life BMI and WC progressively decrease in older adults with normal cognition, aMCI, and AD. Low late-life BMI and WC represent potentially useful pre-clinical markers of aMCI and AD.

引用

页码：223 / 232

页数：10

共 39 条

[1]

American Psychiatric Association, 2000, DIAGN STAT MAN MENT, P133

[2]

Late-life body mass index and dementia incidence: Nine-year follow-up data from the kungsholmen project [J].