Total synthesis of epothilone A: The macrolactonization approach

被引：90

作者：

Nicolaou, KC

Sarabia, F

Ninkovic, S

Yang, Z

机构：

[1] Scripps Res Inst, SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA

[2] UNIV CALIF SAN DIEGO, DEPT CHEM & BIOCHEM, LA JOLLA, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1997年 / 36卷 / 05期

关键词：

antitumor agents; epothilones; macrolactonization; natural products; total synthesis;

D O I：

10.1002/anie.199705251

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：525 / 527

页数：3

共 27 条

[1]

[Anonymous], [No title captured], Patent No. [DE 4138042, 4138042]

[2] Total synthesis of (-)-epothilone A [J].

Balog, A ;

Meng, DF ;

Kamenecka, T ;

Bertinato, P ;

Su, DS ;

Sorensen, EJ ;

Danishefsky, S .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (23-24) :2801-2803

[3]

Balog A., 1996, Angew. Chem, V108, P2976

[4] Studies toward a synthesis of epothilone A: Stereocontrolled assembly of the acyl region and models for macrocyclization [J].

Bertinato, P ;

Sorensen, EJ ;

Meng, DF ;

Danishefsky, SJ .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (23) :8000-8001

[5]

BOLLAG DM, 1995, CANCER RES, V55, P2325

[6]

EMNG D, 1996, J ORG CHEM, V61, P7998

[7] ASYMMETRIC SYNTHESIS VIA METALATED CHIRAL HYDRAZONES - ENANTIOSELECTIVE ALKYLATION OF CYCLIC-KETONES AND ALDEHYDES [J].

ENDERS, D ;

EICHENAUER, H .

CHEMISCHE BERICHTE-RECUEIL, 1979, 112 (08) :2933-2960

[8] ASYMMETRIC-SYNTHESIS OF ALPHA-SUBSTITUTED NITRILES AND CYANOHYDRINS BY OXIDATIVE CLEAVAGE OF CHIRAL ALDEHYDE HYDRAZONES WITH MAGNESIUM MONOPEROXYPHTHALATE [J].

ENDERS, D ;

PLANT, A ;

BACKHAUS, D ;

REINHOLD, U .

TETRAHEDRON, 1995, 51 (39) :10699-10714

[9] ENANTIOSELECTIVE SYNTHESIS AND DETERMINATION OF THE CONFIGURATION OF STENUSINE, THE SPREADING AGENT OF THE BEETLE STENUS-COMMA [J].

ENDERS, D ;

TIEBES, J ;

DEKIMPE, N ;

KEPPENS, M ;

STEVENS, C ;

SMAGGHE, G ;

BETZ, O .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (18) :4881-4884

[10]

Enders D., 1984, ASYMMETRIC SYNTHES B, V3, P275

← 1 2 3 →