Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2

被引：22

作者：

Meenagh, A

Williams, F ^{[1
]}

Sleator, C

Halfpenny, IA

Middleton, D

机构：

[1] City Hosp, No Ireland Reg Histocompatibil & Immunogenet Lab, Belfast BT9 7TS, Antrim, North Ireland

[2] Univ Ulster, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland

来源：

TISSUE ANTIGENS | 2004年 / 64卷 / 03期

关键词：

allele identification; KIR3DL2; KIR genes; SSOP;

D O I：

10.1111/j.1399-0039.2004.00272.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Allelic definition within the killer cell immunoglobulin-like receptor gene, KIR3DL2, has been achieved through a sequence-specific oligonucleotide probe methodology, designed around the specific amplification of the D0 and D1 domains and a section of the cytoplasmic tail of this gene. The system has been applied to a healthy Northern Irish control group, establishing frequencies for this Caucasian population. Additionally, the KIR3DL2 allele status of cell line DNA and Centre d'Etude du Polymorphisme Humain (CEPH) families, both from the 13th International Histocompatibility Workshop, has been established. A high level of KIR3DL2 allelic polymorphism has been identified.

引用

页码：226 / 234

页数：9

共 18 条

[1]

Divergent and convergent evolution of NK-cell receptors [J].