Perinatal management of congenital diaphragmatic hernia

被引：20

作者：

Conforti, Andrea F. ^{[1
]}

Losty, Paul D. ^{[1
]}

机构：

[1] Univ Liverpool, Royal Liverpool Childrens Hosp Alder Hey, Div Child Hlth, Dept Paediat Surg, Liverpool L69 3BX, Merseyside, England

来源：

EARLY HUMAN DEVELOPMENT | 2006年 / 82卷 / 05期

关键词：

congenital diaphragmatic hernia (CDH); fetus; surgery; outcomes;

D O I：

10.1016/j.earlhumdev.2006.02.008

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Congenital diaphragmatic hernia (CDH) retains high mortality due to lung hypoplasia and pulmonary hypertension. Efforts to improve survival and outcome have included fetal intervention, delivery at specialist centres, elective operation after stabilisation of labile physiology and minimising barotrauma. Permissive hypercapnea ('gentle ventilation') represents a significant advance in therapy gaining wider acceptance in centres worldwide. Human genetic studies are underway to identify candidate genes for the birth defect. Progress in the basic sciences may uncover critical aspects of developmental biology fundamental to CDH. Clinical trends in perinatal management of CDH are highlighted, which underpin the challenges of this lethal human anomaly. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

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收藏

页码：283 / 287

页数：5

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