Donepezil and flight simulator performance: Effects on retention of complex skills

被引：99

作者：

Yesavage, JA ^{[1
]}

Mumenthaler, MS

Taylor, JL

Friedman, L

O'Hara, R

Sheikh, J

Tinklenberg, J

Whitehouse, PJ

机构：

[1] Stanford Univ, Dept Psychiat & Behav Sci, Sch Med, Stanford, CA 94305 USA

[2] Palo Alto Vet Affairs Hlth Care Syst, Palo Alto, CA USA

[3] Case Western Reserve Univ, Dept Neurol, Cleveland, OH 44106 USA

[4] Case Western Reserve Univ, Dept Psychiat, Cleveland, OH 44106 USA

[5] Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA

[6] Case Western Reserve Univ, Dept Psychol, Cleveland, OH 44106 USA

[7] Case Western Reserve Univ, Dept Nursing, Cleveland, OH 44106 USA

[8] Case Western Reserve Univ, Dept Org Behav, Cleveland, OH 44106 USA

[9] Case Western Reserve Univ, Dept Biomed Eth, Cleveland, OH 44106 USA

来源：

NEUROLOGY | 2002年 / 59卷 / 01期

关键词：

D O I：

10.1212/WNL.59.1.123

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability to retain the capacity to perform a set of complex simulator tasks than the placebo group, p < 0.05. Donepezil appears to have beneficial effects on retention of training on complex aviation tasks in nondemented older adults.

引用

页码：123 / 125

页数：3

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