New insights into the role of 4-1BB in immune responses:: beyond CD8+ T cells

被引：62

作者：

Kwon, B ^{[1
]}

Lee, HW

Kwon, BS

机构：

[1] Univ Ulsan, Immunomodulat Res Ctr, Ulsan 680749, South Korea

[2] Louisiana State Univ, Hlth Sci Ctr, Ctr Eye, New Orleans, LA 70112 USA

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1471-4906(02)02263-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since the discovery of 4-1BB 15 years ago, the receptor and its ligand (4-1BBL) have remained enigmatic molecules because of their highly regulated pattern of expression Classically, 4-1BB is known to function as a costimulator for T cells and as a potent survival factor for CD8(+) T cells. Recent studies highlight the participation of 4-1BB and its ligand 4-1BBL in a more complex network of immune cell responses and suggest that intervening in the 4-1BB costimulatory pathway might have some potential as a therapeutic approach to immune disorders.

引用

页码：378 / 380

页数：3

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