Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water

被引：51

作者：

Brady, SF ^{[1
]}

Clardy, J ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 08期

关键词：

D O I：

10.1021/np0499766

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Heterologous expression of large fragments of microbial DNA extracted directly from environmental samples (environmental DNA, or eDNA) in easily cultured hosts should provide access to some of the natural products produced by previously uncultured bacteria. The natural product antibiotic palmitoylputrescine (1) was isolated from Escherichia coli transformed with a cosmid (pCSLF16) containing DNA extracted directly from Costa Rican bromeliad tank water. In this report we describe the characterization of this antibiotic and its biosynthetic gene.

引用

页码：1283 / 1286

页数：4

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