Smads as transcriptional co-modulators

被引：553

作者：

Attisano, L ^{[1
]}

Wrana, JL

机构：

[1] Univ Toronto, Dept Anat & Cell Biol, Toronto, ON M5S 1A8, Canada

[2] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Program Mol Biol & Canc, Toronto, ON M5G 1X5, Canada

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(99)00081-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The Smad signalling pathway is critical for transmitting transforming growth factor-beta (TGF-beta) superfamily signals from the cell surface to the nucleus. In the nucleus, Smads regulate transcriptional responses by recruiting co-activators and co-repressors to a wide array of DNA-binding partners. Thus, Smads function as transcriptional co-modulators to regulate TGF beta-dependent gene expression.

引用

页码：235 / 243

页数：9

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