Functional genomics and its implications for molecular medicine

被引：18

作者：

Broeckel, Ulrich

Maresso, Karen

Kugathasan, Subra

机构：

[1] Med Coll Wisconsin, Human & Mol Genet Ctr, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2006年 / 53卷 / 05期

关键词：

D O I：

10.1016/j.pcl.2006.08.007

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Technological development in genetics and genomics provides unprecedented possibilities to identify the underlying molecular basis of many common diseases. With the availability of the human genome sequence and growing information on the most frequent DNA variations combined with the molecular analysis on the RNA expression and protein level, diseases might be characterized in the future at the molecular level. Describing gene function and the specific role of DNA, RNA, and proteins in the disease process provides novel diagnostic tools and treatment. Ultimately, the goal is to provide optimal therapy for each patient. Understanding how the unique genetic signature of an individual influences the risk 66 and prognosis of disease will be the basis for individualized medicine in the years to come.

引用

页码：807 / +

页数：11

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