Quantification by HPLC-MS/MS of atropine in human serum and clinical presentation of six mild-to-moderate intoxicated atropine-adulterated-cocaine users

被引：15

作者：

Boermans, PAMM

Go, HS

Wessels, AMA

Uges, DRA

机构：

[1] IJsselmeerziekenhuizen, Dept Hosp Pharm, NL-8233 AA Lelystad, Netherlands

[2] IJsselmeerziekenhuizen, Dept Internal Med, NL-8233 AA Lelystad, Netherlands

[3] Univ Groningen, Med Ctr, Dept Hosp Pharm, Groningen, Netherlands

来源：

THERAPEUTIC DRUG MONITORING | 2006年 / 28卷 / 03期

关键词：

atropine adulterated cocaine; HPLC-MS/MS; human serum analysis; intoxication;

D O I：

10.1097/01.ftd.0000198537.41835.71

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

An unexpectedly high number of initially suspected cocaine-intoxicated patients was presented to a general hospital in Lelystad, The Netherlands. Based on the unusual toxidram rate of not fitting cocaine intoxication, the suspicion of co-presence of an anticholinergic agent was raised. A newly developed HPLC-MS/MS analytical method revealed the presence of 10% atropine in a cocaine sample retrieved and subsequently in the sera of 6 intoxicated patients.

引用

页码：295 / 298

页数：4

共 6 条

[1] COMPARISON OF RADIORECEPTOR ASSAY AND RADIOIMMUNOASSAY FOR ATROPINE - PHARMACOKINETIC APPLICATION [J].