Mfd, the bacterial transcription repair coupling factor: translocation, repair and termination

被引：70

作者：

Roberts, J

Park, JS

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

[2] Harvard Univ, Biol Labs, Cambridge, MA 02138 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2004年 / 7卷 / 02期

关键词：

D O I：

10.1016/j.mib.2004.02.014

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mfd is a widely conserved bacterial protein that couples DNA repair with transcription. Mfd recognizes RNA polymerase stalled at a non-coding template site of DNA damage, disrupts the transcription complex to release the transcript and enzyme, and recruits the DNA excision repair machinery to the site. The mechanism of RNA release has been illuminated by the discovery that Mfd causes forward translocation of RNA polymerase, using an ATP-dependent motor that is highly homologous to that of the Holliday branch migration protein RecG.

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页码：120 / 125

页数：6

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