Plasma glutamine levels and falciparum malaria

被引：19

作者：

Cowan, G

Planche, T

Agbenyega, T

Bedu-Addo, G

Owusu-Ofori, A

Adebe-Appiah, J

Agranoff, D

Woodrow, C

Castell, L

Elford, B

Krishna, S

机构：

[1] Univ London St Georges Hosp, Sch Med, Dept Infect Dis, London SW17 0RE, England

[2] John Radcliffe Hosp, Inst Mol Med, Dept Mol Parasitol, Oxford OX3 9DU, England

[3] Komfo Anokye Teaching Hosp, Dept Child Hlth, Kumasi, Ghana

[4] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1999年 / 93卷 / 06期

基金：

英国惠康基金;

关键词：

malaria; Plasmodium falciparum; children; glutamine; Ghana;

D O I：

10.1016/S0035-9203(99)90070-6

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 [公共卫生与预防医学]; 120402 [社会医学与卫生事业管理];

摘要：

Glutamine deficiency is associated with increased rates of sepsis and mortality, which can be prevented by glutamine supplementation. Changes in glutamine concentration were examined in Ghanaian children with acute falciparum malaria and control cases. The mean CSD) plasma glutamine concentration was lower in patients with acute malaria (401 (82) mu mol/L, n = 50) than in control patients (623 (67) mu mol/L, n = 7; P < 0 . 001). Plasma glutamine concentrations all rose in convalescence. The mean (SD) increase in plasma glutamine was 202 (123) mu mol/L (n = 18; P < 0 . 001) compared with acute infection. We conclude that acute falciparum malaria is associated with large decreases in plasma glutamine and these fails may increase susceptibility to sepsis and dyserythropoeisis.

引用

页码：616 / 618

页数：3

共 15 条

[1]

OBSERVED RANGE OF ASSAY VALUES FOR PLASMA AND CEREBROSPINAL-FLUID AMINO-ACID LEVELS IN INFANTS AND CHILDREN AGED 3 MONTHS TO 10 YEARS [J].