Combined genome-wide scan for prostate cancer susceptibility genes

被引:53
作者
Gillanders, EM
Xu, JF
Chang, BL
Lange, EM
Wiklund, F
Bailey-Wilson, JE
Baffoe-Bonnie, A
Jones, M
Gildea, D
Riedesel, E
Albertus, J
Isaacs, SD
Wiley, KE
Mohai, CE
Matikainen, MP
Tammela, TLJ
Zheng, SL
Brown, WM
Rökman, A
Carpten, JD
Meyers, DA
Walsh, PC
Schleutker, J
Gronberg, H
Cooney, KA
Isaacs, WB
Trent, JM
机构
[1] NHGRI, NIH, Bethesda, MD 20892 USA
[2] Wake Forest Univ, Sch Med, Ctr Human Genome, Winston Salem, NC 27109 USA
[3] Wake Forest Univ, Sch Med, Dept Publ Hlth, Winston Salem, NC 27109 USA
[4] Umea Univ, Dept Radiat Sci, Umea, Sweden
[5] Fox Chase Canc Ctr, Div Populat Sci, Philadelphia, PA 19111 USA
[6] Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21205 USA
[7] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA
[8] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA
[9] Tampere Univ, Dept Urol, Tampere, Finland
[10] Tampere Univ, Inst Med Technol, Tampere, Finland
[11] Tampere Univ Hosp, Tampere, Finland
[12] Translat Genom Res Inst, Phoenix, AZ USA
来源
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2004年 / 96卷 / 16期
关键词
D O I
10.1093/jnci/djh228
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Prostate cancer represents a substantial public health burden worldwide. It is the second leading cause of cancer death among men in the United States. A family history of the disease is among the most well-established risk factors for prostate cancer. Efforts to localize prostate cancer susceptibility alleles by using genetic linkage analysis methods have been hindered by genetic heterogeneity, incomplete penetrance, disease phenocopies, and the lack of DNA samples from parents of individuals with late-onset prostate cancer. Methods: We performed a combined genome-wide linkage analysis among 426 families from four existing hereditary prostate cancer (HPC) study populations to systematically search for prostate cancer susceptibility genes. To decrease the degree of locus heterogeneity, we analyzed subsets of families with similar clinical and demographic characteristics. Nonparametric multipoint linkage was the primary method of analysis. Results are presented as allele-sharing logarithm of the odds (LOD) scores, and all reported P values are two-sided. Results: The strongest evidence for prostate cancer linkage was found at chromosome region 17q22 (nonparametric multipoint Kong and Cox allele-sharing LOD score = 3.16 at marker D17S787; P = .00007). Stratified analyses revealed several additional chromosomal regions that are likely to segregate prostate cancer susceptibility genes among specific subsets of HPC families, including 15q11 among families with late-onset disease (allele-sharing LOD = 5.57 at marker D15S128; P < .00001) and 4q35 among families with four or more affected family members (allele-sharing LOD = 3.10 at marker D4S1615; P = .00008). Conclusion: Fine mapping studies to facilitate identification of prostate cancer susceptibility genes in these linked regions are warranted.
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收藏
页码:1240 / 1247
页数:8
相关论文
共 39 条
[1]   Merlin-rapid analysis of dense genetic maps using sparse gene flow trees [J].
Abecasis, GR ;
Cherny, SS ;
Cookson, WO ;
Cardon, LR .
NATURE GENETICS, 2002, 30 (01) :97-101
[2]   Evidence for a prostate cancer-susceptibillty locus on chromosome 20 [J].
Berry, R ;
Schroeder, JJ ;
French, AJ ;
McDonnell, SK ;
Peterson, BJ ;
Cunningham, JM ;
Thibodeau, SN ;
Schaid, DJ .
AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (01) :82-91
[3]   Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43 [J].
Berthon, P ;
Valeri, A ;
Cohen-Akenine, A ;
Drelon, E ;
Paiss, T ;
Wöhr, G ;
Latil, A ;
Millasseau, P ;
Mellah, I ;
Cohen, N ;
Blanché, H ;
Bellané-Chantelot, C ;
Demenais, F ;
Teillac, P ;
Le Duc, A ;
de Petriconi, R ;
Hautmann, R ;
Chumakov, I ;
Bachner, L ;
Maitland, NJ ;
Lidereau, R ;
Vogel, W ;
Fournier, G ;
Mangin, P ;
Cohen, D ;
Cussenot, O .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (06) :1416-1424
[4]   Germline mutations in the ribonuclease L gene in families showing linkage with HPC1 [J].
Carpten, J ;
Nupponen, N ;
Isaacs, S ;
Sood, R ;
Robbins, C ;
Xu, J ;
Faruque, M ;
Moses, T ;
Ewing, C ;
Gillanders, E ;
Hu, P ;
Buinovszky, P ;
Makalowska, I ;
Baffoe-Bonnie, A ;
Faith, D ;
Smith, J ;
Stephan, D ;
Wiley, K ;
Brownstein, M ;
Gildea, D ;
Kelly, B ;
Jenkins, R ;
Hostetter, G ;
Matikainen, M ;
Schleutker, J ;
Klinger, K ;
Connors, T ;
Xiang, Y ;
Wang, Z ;
De Marzo, A ;
Papadopoulos, N ;
Kallioniemi, OP ;
Burk, R ;
Meyers, D ;
Grönberg, H ;
Meltzer, P ;
Silverman, R ;
Bailey-Wilson, J ;
Walsh, P ;
Isaacs, W ;
Trent, J .
NATURE GENETICS, 2002, 30 (02) :181-184
[5]   MENDELIAN INHERITANCE OF FAMILIAL PROSTATE-CANCER [J].
CARTER, BS ;
BEATY, TH ;
STEINBERG, GD ;
CHILDS, B ;
WALSH, PC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3367-3371
[6]   Segregation analyses of 1,476 population-based Australian families affected by prostate cancer [J].
Cui, JS ;
Staples, MP ;
Hopper, JL ;
English, DR ;
McCredie, MRE ;
Giles, GG .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (05) :1207-1218
[7]   Mutations in CHEK2 associated with prostate cancer risk [J].
Dong, XY ;
Wang, L ;
Taniguchi, K ;
Wang, XS ;
Cunningham, JM ;
McDonnell, SK ;
Qian, CP ;
Marks, AF ;
Slager, SL ;
Peterson, BJ ;
Smith, BI ;
Cheville, JC ;
Blute, ML ;
Jacobsen, SJ ;
Schaid, DJ ;
Tindall, DJ ;
Thibodeau, SN ;
Liu, WG .
AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (02) :270-280
[8]   Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene [J].
Edwards, SM ;
Kote-Jarai, Z ;
Meitz, J ;
Hamoudi, R ;
Hope, Q ;
Osin, P ;
Jackson, R ;
Southgate, C ;
Singh, R ;
Falconer, A ;
Dearnaley, DP ;
Ardern-Jones, A ;
Murkin, A ;
Dowe, A ;
Kelly, J ;
Williams, S ;
Oram, R ;
Stevens, M ;
Teare, DM ;
Ponder, BAJ ;
Gayther, SA ;
Easton, DF ;
Eeles, RA .
AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (01) :1-12
[9]   Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36 [J].
Gibbs, M ;
Stanford, JL ;
McIndoe, RA ;
Jarvik, GP ;
Kolb, S ;
Goode, EL ;
Chakrabarti, L ;
Schuster, EF ;
Buckley, VA ;
Miller, EL ;
Brandzel, S ;
Li, S ;
Hood, L ;
Ostrander, EA .
AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 64 (03) :776-787
[10]   Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4 [J].
Goddard, KAB ;
Witte, JS ;
Suarez, BK ;
Catalona, WJ ;
Olson, JM .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (05) :1197-1206