Prion research: the next frontiers

被引：188

作者：

Aguzzi, A ^{[1
]}

Weissmann, C ^{[1
]}

机构：

[1] UNIV ZURICH, INST MOL BIOL, CH-8091 ZURICH, SWITZERLAND

来源：

NATURE | 1997年 / 389卷 / 6653期

关键词：

D O I：

10.1038/39758

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although the precise structure of the infectious agent that causes priori diseases is still unknown, important features of its molecular genetics have been elucidated. The transmissibility of BSE to humans dramatically highlights the need to understand priori biology fully.

引用

页码：795 / 798

页数：4

共 35 条

[1] Spongiform encephalopathies - A suspicious signature
Aguzzi, A
Weissmann, C
[J]. NATURE, 1996, 383 (6602) : 666 - 667
[2] SCRAPIE AND CELLULAR PRP ISOFORMS ARE ENCODED BY THE SAME CHROMOSOMAL GENE
BASLER, K
OESCH, B
SCOTT, M
WESTAWAY, D
WALCHLI, M
GROTH, DF
MCKINLEY, MP
PRUSINER, SB
WEISSMANN, C
[J]. CELL, 1986, 46 (03) : 417 - 428
[3] DISTINCT PRP PROPERTIES SUGGEST THE MOLECULAR-BASIS OF STRAIN VARIATION IN TRANSMISSIBLE MINK ENCEPHALOPATHY
BESSEN, RA
MARSH, RF
[J]. JOURNAL OF VIROLOGY, 1994, 68 (12) : 7859 - 7868
[4] NONGENETIC PROPAGATION OF STRAIN-SPECIFIC PROPERTIES OF SCRAPIE PRION PROTEIN
BESSEN, RA
KOCISKO, DA
RAYMOND, GJ
NANDAN, S
LANSBURY, PT
CAUGHEY, B
[J]. NATURE, 1995, 375 (6533) : 698 - 700
[5] Blaettler Thomas, 1997, Nature (London), V389, P69
[6] Normal host prion protein (PrPc) is required for scrapie spread within the central nervous system
Brandner, S
Raeber, A
Sailer, A
Blattler, T
Fischer, M
Weissmann, C
Aguzzi, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) : 13148 - 13151
[7] Normal host prion protein necessary for scrapie-induced neurotoxicity
Brandner, S
Isenmann, S
Raeber, A
Fischer, M
Sailer, A
Kobayashi, Y
Marino, S
Weissmann, C
Aguzzi, A
[J]. NATURE, 1996, 379 (6563) : 339 - 343
[8] Role of microglia and host prion protein in neurotoxicity of a prion protein fragment
Brown, DR
Schmidt, B
Kretzschmar, HA
[J]. NATURE, 1996, 380 (6572) : 345 - 347
[9] THE NEW BIOLOGY OF SPONGIFORM ENCEPHALOPATHY - INFECTIOUS AMYLOIDOSES WITH A GENETIC TWIST
BROWN, P
GOLDFARB, LG
GAJDUSEK, DC
[J]. LANCET, 1991, 337 (8748) : 1019 - 1022
[10] Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent
Bruce, ME
Will, RG
Ironside, JW
McConnell, I
Drummond, D
Suttie, A
McCardle, L
Chree, A
Hope, J
Birkett, C
Cousens, S
Fraser, H
Bostock, CJ
[J]. NATURE, 1997, 389 (6650) : 498 - 501

← 1 2 3 4 →