Sequence-specific DNA recognition by polyamides

被引：292

作者：

Dervan, PB ^{[1
]}

Bürli, RW ^{[1
]}

机构：

[1] CALTECH, Dept Chem, Pasadena, CA 91125 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1367-5931(99)00027-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sequence-specific DNA-binding small molecules that can permeate cells could potentially regulate transcription of specific genes. Simple pairing rules for the minor groove of the double helix have been developed that allow the design of ligands for predetermined DNA sequences. Some of these polyamides have been shown to inhibit specific gene expression in mammalian cell culture.

引用

页码：688 / 693

页数：6

共 47 条

[1] Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids
Baird, EE
Dervan, PB
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (26) : 6141 - 6146
[2] 2ND STRUCTURAL MOTIF FOR RECOGNITION OF DNA BY OLIGONUCLEOTIDE-DIRECTED TRIPLE-HELIX FORMATION
BEAL, PA
DERVAN, PB
[J]. SCIENCE, 1991, 251 (4999) : 1360 - 1363
[3] Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch
Bremer, RE
Baird, EE
Dervan, PB
[J]. CHEMISTRY & BIOLOGY, 1998, 5 (03): : 119 - 133
[4] Physical basis of a protein-DNA recognition code
Choo, Y
Klug, A
[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 1997, 7 (01) : 117 - 125
[5] NMR characterization of the aliphatic β/β pairing for recognition of a A•T/T•A base pairs in the minor groove of DNA
de Clairac, RPL
Seel, CJ
Geierstanger, BH
Mrksich, M
Baird, EE
Dervan, PB
Wemmer, DE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (13) : 2956 - 2964
[6] NMR characterization of hairpin polyamide complexes with the minor groove of DNA
deClairac, RPL
Geierstanger, BH
Mrksich, M
Dervan, PB
Wemmer, DE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (34) : 7909 - 7916
[7] DESIGN OF SEQUENCE-SPECIFIC DNA-BINDING MOLECULES
DERVAN, PB
[J]. SCIENCE, 1986, 232 (4749) : 464 - 471
[8] MOLECULAR RECOGNITION OF DNA BY SMALL MOLECULES - SYNTHESIS OF BIS(METHIDIUM)SPERMINE, A DNA POLYINTERCALATING MOLECULE
DERVAN, PB
BECKER, MM
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (06) : 1968 - 1970
[9] Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands
Dickinson, LA
Gulizia, RJ
Trauger, JW
Baird, EE
Mosier, DE
Gottesfeld, JM
Dervan, PB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) : 12890 - 12895
[10] Regulation of gene expression by small molecules
Gottesfeld, JM
Neely, L
Trauger, JW
Baird, EE
Dervan, PB
[J]. NATURE, 1997, 387 (6629) : 202 - 205

← 1 2 3 4 5 →