The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

被引：307

作者：

Amit, Ido ^{[1
]}

Winter, Deborah R. ^{[1
]}

Jung, Steffen ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 01期

基金：

欧洲研究理事会; 以色列科学基金会;

关键词：

DETERMINING TRANSCRIPTION FACTORS; DENDRITIC CELL; HISTONE MODIFICATIONS; LY6C(HI) MONOCYTES; ANALYSIS REVEALS; FETAL MONOCYTES; SPI-C; MICROGLIA; CHROMATIN; GENE;

D O I：

10.1038/ni.3325

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Macrophages provide a critical systemic network cells of the innate immune system. Emerging data suggest that in addition, they have important tissue-specific functions that range from clearance of surfactant from the lungs to neuronal pruning and establishment of gut homeostasis. The differentiation and tissue-specific activation of macrophages require precise regulation of gene expression, a process governed by epigenetic mechanisms such as DNA methylation, histone modification and chromatin structure. We argue that epigenetic regulation of macrophages is determined by lineage- and tissue-specific transcription factors controlled by the built-in programming of myeloid development in combination with signaling from the tissue environment. Perturbation of epigenetic mechanisms of tissue macrophage identity can affect normal macrophage tissue function and contribute to pathologies ranging from obesity and autoimmunity to neurodegenerative diseases.

引用

页码：18 / 25

页数：8

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