Detection of microcalcifications in digital mammograms using wavelet filter and Markov random field model

Clustered microcalcifcations (MCs) in digitized mammograms has been widely recognized as an early sign of breast cancer in women. This work is devoted to developing a computer-aided diagnosis (CAD) system for the detection of MCs in digital mammograms. Such a task actually involves two key issues: detection of suspicious MCs and recognition of true MCs. Accordingly, our approach is divided into two stages. At first, all suspicious MCs are preserved by thresholding a filtered mammogram via a wavelet filter according to the MPV (mean pixel value) of that image. Subsequently, Markov random field parameters based on the Derin-Elliott model are extracted from the neighborhood of every suspicious MCs as the primary texture features. The primary features combined with three auxiliary texture quantities serve as inputs to classifiers for the recognition of true MCs so as to decrease the false positive rate. Both Bayes classifier and back-propagation neural network were used for computer experiments. The data used to test this method were 20 mammograms containing 25 areas of clustered MCs marked by radiologists. Our method can readily remove 1341 false positives out of 1356, namely, 98.9% false positives were removed. Additionally, the sensitivity (true positives rate) is 92%, with only 0.75 false positives per image. From our experiments, we conclude that, with a proper choice of classifier, the texture feature based on Markov random field parameters combined with properly designed auxiliary features extracted from the texture context of the MCs can work outstandingly in the recognition of MCs in digital mammograms. (c) 2006 Elsevier Ltd. All rights reserved.