Preparation and radiolabeling of surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy

被引：136

作者：

Cao, JQ

Wang, YX

Yu, JF

Xia, JY

Zhang, CF

Yin, DZ

Häfeli, UO

机构：

[1] Chinese Acad Sci, Shanghai Inst Nucl Res, Shanghai 201800, Peoples R China

[2] Cleveland Clin Fdn, Radiat Oncol Dept T28, Cleveland, OH 44195 USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2004年 / 277卷 / 1-2期

关键词：

magnetic nanoparticles; histidine; rhenium-188; tricarbonyl complex; radiolabeling;

D O I：

10.1016/j.jmmm.2003.10.022

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Magnetite nanoparticles coated with silica were synthesized and characterized by electron microscopic methods (SEM and TEM) and crystal structure analysis (XRD). After surface modification with an amino silane coupling agent, N-[3-(trimethyoxysilyl) propyl]-ethylenediamine (SG-Si900), histidine was covalently linked to the amine group using glutaraldehyde as cross.-linker. The magnetic nanoparticles were then radiolabeled with Re-188 with a labeling yield of 91.4 +/- 0.3% and good stability in vitro. The labeling mechanism is suggested as fac-[Re-188(CO)(3)(H2O)(3)](+) core complexed with imidazolyl groups. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：165 / 174

页数：10

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