A preliminary study of magnetization transfer and diffusion tensor MRI of multiple sclerosis patients with fatigue

被引：47

作者：

Codella, M

Rocca, MA

Colombo, B

Rossi, P

Comi, G

Filippi, M

机构：

[1] San Raffaele Sci Inst, Dept Neurosci, Neuroimaging Res Unit, I-20132 Milan, Italy

[2] Univ Milan, Osped San Raffaele, I-20132 Milan, Italy

来源：

JOURNAL OF NEUROLOGY | 2002年 / 249卷 / 05期

关键词：

multiple sclerosis fatigue; magnetic resonance imaging; magnetization transfer imaging; diffusion tensor imaging;

D O I：

10.1007/s004150200060

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To investigate whether multiple sclerosis (MS) tissue damage is associated with the presence and severity of fatigue, we obtained magnetization transfer (MT) and diffusion tensor (DT) magnetic resonance imaging from 28 patients with MS (14 with and 14 without fatigue). MT ratio and mean diffusivity did not differ between fatigued and non-fatigued MS patients. No correlation was found between Fatigue Severity Scale scores and any of the MT and DT MRI-derived quantities. This preliminary study suggests that the severity of overall MS pathology in the brain seems not to be a critical factor contributing to the development of fatigue in MS.

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收藏

页码：535 / 537

页数：3

相关论文

共 10 条

[1] HISTOLOGICAL, HISTOCHEMICAL AND BIOCHEMICAL-STUDY OF THE MACROSCOPICALLY NORMAL WHITE MATTER IN MULTIPLE-SCLEROSIS [J].

ALLEN, IV ;

MCKEOWN, SR .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1979, 41 (01) :81-91

[2] Fatigue in multiple sclerosis: Cross-sectional correlation with brain MRI findings in 71 patients [J].

Bakshi, R ;

Miletich, RS ;

Henschel, K ;

Shaikh, ZA ;

Janardhan, V ;

Wasay, M ;

Stengel, LM ;

Ekes, R ;

Kinkel, PR .

NEUROLOGY, 1999, 53 (05) :1151-1153

[3]

Cercignani M, 2001, AM J NEURORADIOL, V22, P952

[4] MRI and motor evoked potential findings in nondisabled multiple sclerosis patients with and without symptoms of fatigue [J].

Colombo, B ;

Boneschi, FM ;

Rossi, P ;

Rovaris, M ;

Maderna, L ;

Filippi, M ;

Comi, G .

JOURNAL OF NEUROLOGY, 2000, 247 (07) :506-509

[5] Magnetization transfer imaging to monitor the evolution of MS - A 1-year follow-up study [J].

Filippi, M ;

Inglese, M ;

Rovaris, M ;

Sormani, MP ;

Horsfield, MA ;

Iannucci, G ;

Colombo, B ;

Comi, G .

NEUROLOGY, 2000, 55 (07) :940-946

[6] FATIGUE IN MULTIPLE-SCLEROSIS [J].

KRUPP, LB ;

ALVAREZ, LA ;

LAROCCA, NG ;

SCHEINBERG, LC .

ARCHIVES OF NEUROLOGY, 1988, 45 (04) :435-437

[7] Fatigue and magnetic resonance imaging activity in multiple sclerosis [J].

Mainero, C ;

Faroni, J ;

Gasperini, C ;

Filippi, M ;

Giugni, E ;

Ciccarelli, O ;

Rovaris, M ;

Batianello, S ;

Comi, G ;

Pozzilli, C .

JOURNAL OF NEUROLOGY, 1999, 246 (06) :454-458

[8] Evidence for adaptive functional changes in the cerebral cortex with axonal injury from multiple sclerosis [J].

Reddy, H ;

Narayanan, S ;

Arnoutelis, R ;

Jenkinson, M ;

Antel, J ;

Matthews, PM ;

Arnold, DL .

BRAIN, 2000, 123 :2314-2320

[9] Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: A F-18-fluorodeoxyglucose positron emission tomography study [J].

Roelcke, U ;

Kappos, L ;

LechnerScott, J ;

Brunnschweiler, H ;

Huber, S ;

Ammann, W ;

Plohmann, A ;

Dellas, S ;

Maguire, RP ;

Missimer, J ;

Radu, EW ;

Steck, A ;

Leenders, KL .

NEUROLOGY, 1997, 48 (06) :1566-1571

[10] Fatigue in multiple sclerosis: Interrelations between fatigue complaints, cerebral MRI abnormalities and neurological disability [J].

van der Werf, SP ;

Jongen, PJH ;

Nijeholt, GJLA ;

Barkhof, F ;

Hommes, OR ;

Bleijenberg, G .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1998, 160 (02) :164-170