Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus

被引：217

作者：

Benedetti, F

Colloca, L

Torre, E

Lanotte, M

Melcarne, A

Pesare, M

Bergamasco, B

Lopiano, L

机构：

[1] Univ Turin, Sch Med, Dept Neurosci, Clin & Appl Physiol Program, I-10125 Turin, Italy

[2] Univ Turin, Sch Med, Dept Neurosci, Neurol Clin, I-10126 Turin, Italy

[3] CTO Med Ctr, Div Neurosurg, I-10126 Turin, Italy

[4] Maugeri Fdn, I-27100 Pavia, Italy

来源：

NATURE NEUROSCIENCE | 2004年 / 7卷 / 06期

关键词：

D O I：

10.1038/nn1250

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Placebo administration is known to affect the brain both in pain and in Parkinson disease. Here we show that placebo treatment caused reduced activity in single neurons in the subthalamic nucleus of placebo-responsive Parkinsonian patients. These changes in activity were tightly correlated with clinical improvement; no decrease in activity occurred when the clinical placebo response was absent.

引用

页码：587 / 588

页数：2

共 15 条

[1] Neuropharmacological dissection of placebo analgesia: Expectation-activated opioid systems versus conditioning-activated specific subsystems [J].