A multigram, stereoselective synthesis of D-[C-13(5)]ribose from D-[C-13(6)]glucose and its conversion into [C-13(5)]nucleosides

被引：28

作者：

Agrofoglio, LA ^{[1
]}

Jacquinet, JC ^{[1
]}

Lancelot, G ^{[1
]}

机构：

[1] CNRS,CTR BIOPHYS MOL,F-45071 ORLEANS 2,FRANCE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(97)00080-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of C-13-labeled ribonucleosides starting from D-[C-13(6)]glucose in 45% overall yield is described. The key of this short synthetic way is the dehomologation of di-O-isopropylidene hexofuranose 2 with periodic acid and NaBH4 that afforded stereoselectively the labeled ribofuranose derivative 3 in high yield. (C) 1997 Elsevier Science Ltd.

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页码：1411 / 1412

页数：2

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