Landing of immune receptors and signal proteins on lipid rafts:: a safe way to be spatio-temporally coordinated?

被引：29

作者：

Matkó, J

Szöllosi, J

机构：

[1] Eotvos Lorand Univ, Dept Immunol, H-1117 Budapest, Hungary

[2] Univ Debrecen, Fac Med, Med & Hlth Sci Ctr, Dept Biophys & Cell Biol, H-4012 Debrecen, Hungary

来源：

IMMUNOLOGY LETTERS | 2002年 / 82卷 / 1-2期

关键词：

lipid rafts; protein mobility; scanning microscopy; detergent resistance; immune synapses; MIRR; signal transduction;

D O I：

10.1016/S0165-2478(02)00011-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the past decade one of the cell biology's breakthroughs was discovery of membrane microdomains (rafts, caveolae) and recognition of their important in cellular signaling and protein traffic. In the present minireview a short comprehensive overview is given about physico-chemical, structural and functional properties of rafts. In addition to the classical immunochemical techniques the latest physcial and biophysical technologies that can be used to study these microdomains are also described briefly. The funcational significance of rafts in signaling of multichain immune recognition receptors (MIRRs), the IL-2R and ErbB family factor receptors is also discussed herein together with the still open questions and future prospects of the raft hypothesis. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：3 / 15

页数：13

共 100 条

[1] On the origin of sphingolipid/cholesterol-rich detergent-insoluble cell membranes: Physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes [J].