Adhesion dependent signalling in the tumour microenvironment: The future of drug targetting

被引：22

作者：

Bewick, Mary A. ^{[1
]}

Lafrenie, Robert M. ^{[1
]}

机构：

[1] Hop Reg Sudbury, Integrated Canc Program, Sudbury, ON P3E 5J1, Canada

来源：

CURRENT PHARMACEUTICAL DESIGN | 2006年 / 12卷 / 22期

关键词：

adhesion; cancer; drug targeting; microenvironment; signalling;

D O I：

10.2174/138161206777947704

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cellular adhesion molecules are critical components during carcinogenesis and cancer metastasis and contribute to the mechanisms underlying resistance to chemotherapeutic drugs. Since drug resistance is associated-with a very poor prognosis for patients with cancer, a better understanding of the role of adhesion molecules could improve patient outcome by identifying novel mechanisms that promote drug resistance. Epigenctic factors, such as cellular adhesion, are shown to promote the resistance of cancers to various chemotherapeutic drugs by altering cellular signalling pathways that activate cellular growth and inhibit apoptosis. In addition, cellular adhesion molecules can provide a means to specifically target more conventional chemotherapy to the unique tumour microenvironment. However, the expression and function of cellular adhesion molecules, and the signals activated by adhesion, are highly interrelated making the development of rational therapies more difficult.

引用

页码：2833 / 2848

页数：16

共 226 条

[1]

Adachi M, 2000, CLIN CANCER RES, V6, P96

[2] Ras signaling pathway proteins as therapeutic targets [J].

Adjei, AA .

CURRENT PHARMACEUTICAL DESIGN, 2001, 7 (16) :1581-1594

[3] Signal transduction pathway targets for anticancer drug discovery [J].

Adjei, AA .

CURRENT PHARMACEUTICAL DESIGN, 2000, 6 (04) :361-378

[4]

Alattia Jean-Rene, 2002, Methods Mol Biol, V172, P199

[5]

ALBELDA SM, 1993, LAB INVEST, V68, P4

[6] Clinical significance of serum levels of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in gastric cancer patients [J].

Alexiou, D ;

Karayiannakis, AJ ;

Syrigos, KN ;

Zbar, A ;

Sekara, E ;

Michail, P ;

Rosenberg, T ;

Diamantis, T .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2003, 98 (02) :478-485

[7] Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery [J].

Alexiou, D ;

Karayiannakis, AJ ;

Syrigos, KN ;

Zbar, A ;

Kremmyda, A ;

Bramis, I ;

Tsigris, C .

EUROPEAN JOURNAL OF CANCER, 2001, 37 (18) :2392-2397

[8] Intercellular cell adhesion molecule-1,vascular cell adhesion molecule-1, and regulated on activation normal T cell expressed and secreted are expressed by human breast carcinoma cells and support eosinophil adhesion and activation [J].

Ali, S ;

Kaur, J ;

Patel, KD .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (01) :313-321

[9] Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: Implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma [J].

Amiri, KI ;

Horton, LW ;

LaFleur, BJ ;

Sosman, JA ;

Richmond, A .

CANCER RESEARCH, 2004, 64 (14) :4912-4918

[10]

Aplin AE, 1998, PHARMACOL REV, V50, P197

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