The association between high VEGF levels and multiple probable punctuate cavernous malformations

被引：19

作者：

Abe, Tatsuya ^{[1
]}

Morishige, M. ^{[1
]}

Ooba, H. ^{[1
]}

Kamida, T. ^{[1
]}

Fujiki, M. ^{[1
]}

Kobayashi, H. ^{[1
]}

Sakoda, T. ^{[2
]}

Kimba, Y. ^{[2
]}

机构：

[1] Oita Univ, Sch Med, Dept Neurosurg, Oita 8795593, Japan

[2] Beppu Chuo Hosp, Dept Neurosurg, Oita 8740928, Japan

来源：

ACTA NEUROCHIRURGICA | 2009年 / 151卷 / 07期

关键词：

Cavernous malformations; VEGF; TGF-1; beta; Growth factors; Progression; CEREBRAL MICROBLEEDS; ISCHEMIC-STROKE; RISK-FACTOR; MRI; HEMORRHAGES; EXPRESSION; ANGIOMAS; LESIONS;

D O I：

10.1007/s00701-009-0410-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Cerebral cavernous malformations (CCMs) are congenital abnormalities of the cerebral vessels. The de novo development of new lesions in this disease has been reported. However, the underlying mechanism of progressive CCMs in such patients remains unclear. This report documents two cases of multiple probable CCMs that showed a progressive behaviour. The plasma levels of vascular endothelial growth factor (VEGF), and transforming growth factor-beta 1 (TGF-beta 1) were measured using an enzyme-linked immunosorbent assay (ELISA). The concentration of both VEGF and TGF-beta 1 in plasma was increased in these patients. A relationship was observed between high concentrations of growth factors and progressive CCMs. Even though a causal linkage between these conditions cannot be confirmed, a continuous high VEGF level in plasma could be a possible clinical indicator for subsequent intracerebral haemorrhages in the CCM patients.

引用

页码：855 / 859

页数：5

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