Synthesis of five-, six-, and seven-membered ring lactams by Cp*Rh complex-catalyzed oxidative N-heterocyclization of amino alcohols

被引：197

作者：

Fujita, K ^{[1
]}

Takahashi, Y ^{[1
]}

Owaki, M ^{[1
]}

Yamamoto, K ^{[1
]}

Yamaguchi, R ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Human & Environm Studies, Kyoto 6068501, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 16期

关键词：

D O I：

10.1021/ol0489954

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new effective catalytic system consisting of [Cp*RhCl2](2)/K2CO3 (CP* = pentamethylcyclopentadienyl) for the lactamization of amino alcohols has been developed. As an example, the reaction of 3-(2-aminophenyl)-1-propanol in the presence of [Cp*RhCl2](2) (5.0% Rh) and K2CO3 (10%) in acetone gives 3,4-dihydro-2(1h)-quinolinone in an isolated yield of 80%. A variety of five-, six-, and seven-membered benzo-fused lactams are synthesized by this catalytic system.

引用

页码：2785 / 2788

页数：4

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