Podophyllotoxin:: distribution, sources, applications and new cytotoxic derivatives

被引：568

作者：

Gordaliza, M ^{[1
]}

García, PA ^{[1
]}

del Corral, JMM ^{[1
]}

Castro, MA ^{[1
]}

Gómez-Zurita, MA ^{[1
]}

机构：

[1] Univ Salamanca, Fac Farm, Dept Quim Farmaceut, E-37007 Salamanca, Spain

来源：

TOXICON | 2004年 / 44卷 / 04期

关键词：

podophyllotoxin; isoxazopodophyllic acid; cyclolignan; cytotoxicity;

D O I：

10.1016/j.toxicon.2004.05.008

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity on several neoplastic cell lines. Chemical transformations performed on these compounds have yielded derivatives more potent and more selective that the parent compound. Most of the compounds maintained their cytotoxicity at the muM level. Distribution, biosynthesis, production, biotechnology, applications and synthesis have also been reviewed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：441 / 459

页数：19

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