Long-term use of temozolomide: Could you use temozolomide safely for life in gliomas?

被引：26

作者：

Khasraw, Mustafa ^{[1
]}

Bell, David ^{[1
]}

Wheeler, Helen ^{[1
]}

机构：

[1] Royal N Shore Hosp, Dept Med Oncol, St Leonards, NSW 2065, Australia

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2009年 / 16卷 / 06期

关键词：

Temozolomide; Glioma; Glioblastoma multiforme; HIGH-GRADE GLIOMA;

D O I：

10.1016/j.jocn.2008.09.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Temozolomide (TMZ) is an alkylating agent used in the management of gliomas. Although TMZ is generally safe and acute toxicity is well documented, there are limited data on long-term toxicities. We present three patients with glioma; all patients started on TMZ after having progressed following primary treatment. These patients have continued TMZ for 5 years, 7 years and 8 years respectively. So far they have had no serious side effects. We discuss these patients while raising the question of prolonged TMZ use. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

引用

页码：854 / 855

页数：2

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