Adaptations to a Subterranean Environment and Longevity Revealed by the Analysis of Mole Rat Genomes

被引：164

作者：

Fang, Xiaodong ^{[1
,2
]}

Seim, Inge ^{[3
,4
]}

Huang, Zhiyong ^{[1
]}

Gerashchenko, Maxim V. ^{[3
]}

Xiong, Zhiqiang ^{[1
]}

Turanov, Anton A. ^{[3
]}

Zhu, Yabing ^{[1
]}

Lobanov, Alexei V. ^{[3
]}

Fan, Dingding ^{[1
]}

Yim, Sun Hee ^{[3
]}

Yao, Xiaoming ^{[1
]}

Ma, Siming ^{[3
]}

Yang, Lan ^{[1
]}

Lee, Sang-Goo ^{[3
,4
]}

Kim, Eun Bae ^{[4
]}

Bronson, Roderick T. ^{[5
]}

Sumbera, Radim ^{[6
]}

Buffenstein, Rochelle ^{[7
,8
]}

Zhou, Xin ^{[1
]}

Krogh, Anders ^{[2
]}

Park, Thomas J. ^{[9
]}

Zhang, Guojie ^{[1
,2
]}

Wang, Jun ^{[1
,2
,10
]}

Gladyshev, Vadim N. ^{[3
,4
]}

机构：

[1] BGI Shenzhen, Shenzhen 518083, Peoples R China

[2] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen N, Denmark

[3] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Div Genet, Boston, MA 02115 USA

[4] Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South Korea

[5] Harvard Univ, Sch Med, Rodent Histopathol Lab, Boston, MA 02115 USA

[6] Univ South Bohemia, Fac Sci, Ceske Budejovice 37005, Czech Republic

[7] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78245 USA

[8] Univ Texas Hlth Sci Ctr San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78245 USA

[9] Univ Illinois, Dept Biol Sci, Chicago, IL 60607 USA

[10] King Abdulaziz Univ, Jeddah 21441, Saudi Arabia

来源：

CELL REPORTS | 2014年 / 8卷 / 05期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

LONGEST-LIVING RODENT; HETEROCEPHALUS-GLABER; CANCER RESISTANCE; RIBOSOMAL-RNA; INSULIN; GENE; SEQUENCE; EXPRESSION; EVOLUTION; GROWTH;

D O I：

10.1016/j.celrep.2014.07.030

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Subterranean mammals spend their lives in dark, unventilated environments that are rich in carbon dioxide and ammonia and low in oxygen. Many of these animals are also long-lived and exhibit reduced aging- associated diseases, such as neurodegenerative disorders and cancer. We sequenced the genome of the Damaralandmole rat (DMR, Fukomys damarensis) and improved the genome assembly of the naked mole rat (NMR, Heterocephalus glaber). Comparative genome analyses, along with the transcriptomes of related subterranean rodents, revealed candidate molecular adaptations for subterranean life and longevity, including a divergent insulin peptide, expression of oxygen-carrying globins in the brain, prevention of high CO2-induced pain perception, and enhanced ammonia detoxification. Juxtaposition of the genomes of DMR and other more conventional animals with the genome of NMR revealed several truly exceptional NMR features: unusual thermogenesis, an aberrant melatonin system, pain insensitivity, and unique processing of 28S rRNA. Together, these genomes and transcriptomes extend our understanding of subterranean adaptations, stress resistance, and longevity.

引用

页码：1354 / 1364

页数：11

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