The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans

被引：100

作者：

Kruppa, M ^{[1
]}

Krom, BP ^{[1
]}

Chauhan, N ^{[1
]}

Bambach, AV ^{[1
]}

Cihlar, RL ^{[1
]}

Calderone, RA ^{[1
]}

机构：

[1] Georgetown Univ, Dept Microbiol & Immunol, Ctr Med, Washington, DC 20057 USA

来源：

EUKARYOTIC CELL | 2004年 / 3卷 / 04期

关键词：

D O I：

10.1128/EC.3.4.1062-1065.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Regulation of hyphal morphogenesis in Candida albicans can occur through quorum sensing (QS). A QS signal, farnesol, is produced during high-density growth and inhibits morphogenesis. However, the signal transduction pathway that regulates QS is unknown. Here, we show that a C albicans mutant lacking Chk1p but not either the Sln1p or the Nik1p histidine kinase is refractory to the inhibitory effect of farnesol both in cell suspension and during the formation of a biofilm. This study is the first to demonstrate a role for a two-component signal transduction protein in QS by a eukaryotic organism.

引用

页码：1062 / 1065

页数：4

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