Co-localization of glucokinase with actin filaments

被引：24

作者：

Murata, T

Katagiri, H

Ishihara, H

Shibasaki, Y

Asano, T

Toyoda, Y

Pekiner, B

Pekiner, C

Miwa, I

Oka, Y

机构：

[1] YAMAGUCHI UNIV,SCH MED,DEPT INTERNAL MED 3,UBE,YAMAGUCHI 755,JAPAN

[2] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,BUNKYO KU,TOKYO 113,JAPAN

[3] MEIJO UNIV,FAC PHARM,DEPT PATHOBIOCHEM,TEMPAKU KU,NAGOYA,AICHI 468,JAPAN

来源：

FEBS LETTERS | 1997年 / 406卷 / 1-2期

关键词：

liver glucokinase; islet glucokinase; actin filament;

D O I：

10.1016/S0014-5793(97)00253-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A portion of glucokinase appeared to be co-localized with actin filaments in the cytoplasm of cultured rat hepatocytes incubated with 25 mM glucose, When liver- or islet-type glucokinase was transiently expressed in COS-7 cells, the expressed glucokinase mas also co-localized with actin filaments in the cytoplasm of these transfected cells, Although colocalization of glucokinase with actin filaments was not clearly demonstrated in the pancreatic beta-cell line MIN6, islet glucokinase was found to be present in both the nucleus and the cytoplasm, though predominantly in the nucleus, These findings suggest that subcellular localization of glucokinase, including colocalization with actin filaments, may have an important physiological role in metabolic regulation. (C) 1997 Federation of European Biochemical Societies.

引用

页码：109 / 113

页数：5

共 18 条

[1] INTRACELLULAR BINDING OF GLUCOKINASE IN HEPATOCYTES AND TRANSLOCATION BY GLUCOSE, FRUCTOSE AND INSULIN [J].