A brief review of methods for terminal functionalization of DNA

被引：29

作者：

Dong, Yuanchen ^{[1
]}

Liu, Dongsheng ^{[1
]}

Yang, Zhongqiang ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China

来源：

METHODS | 2014年 / 67卷 / 02期

基金：

中国国家自然科学基金;

关键词：

DNA; Terminal functionalization; Solid-phase functionalization; Solution coupling functionalization; HYDROXYSULFOSUCCINIMIDE ACTIVE ESTERS; NUCLEIC-ACID NANOSTRUCTURES; CLICK CHEMISTRY; CROSS-LINKING; DEOXYNUCLEOSIDE PHOSPHORAMIDITES; MODIFIED OLIGONUCLEOTIDES; MEMBRANE-IMPERMEANT; TEMPLATED SYNTHESIS; BLOCK-COPOLYMERS; NANOSCALE SHAPES;

D O I：

10.1016/j.ymeth.2013.11.004

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The functionalized DNA has been widely developed and played a more and more important role in life science and material science during last decades. Therefore, methods to effectively endue DNA new functions by modifying DNA have been developed quickly. In this review, we will give an introduction in the methods for covalent terminal functionalization of DNA, including solid-phase functionalization and solution coupling functionalization, mainly on the technical aspect. The application of these functionalized DNA will be also introduced. (C) 2014 Published by Elsevier Inc.

引用

页码：116 / 122

页数：7

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