Tracing PAKs from GI inflammation to cancer

被引：60

作者：

Dammann, Kyle

Khare, Vineeta

Gasche, Christoph

机构：

[1] Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Med 3, A-1090 Vienna, Austria

[2] Med Univ Vienna, Christian Doppler Lab Mol Canc Chemoprevent, A-1090 Vienna, Austria

来源：

GUT | 2014年 / 63卷 / 07期

基金：

奥地利科学基金会;

关键词：

P21-ACTIVATED PROTEIN-KINASE; ENTEROPATHOGENIC ESCHERICHIA-COLI; TIGHT JUNCTION PERMEABILITY; BETA-CATENIN; COLORECTAL-CANCER; HELICOBACTER-PYLORI; CELL-ADHESION; NUCLEAR-LOCALIZATION; GASTRIC-CANCER; GROUP-I;

D O I：

10.1136/gutjnl-2014-306768

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

P-21 activated kinases (PAKs) are effectors of Rac1/Cdc42 which coordinate signals from the cell membrane to the nucleus. Activation of PAKs drive important signalling pathways including mitogen activated protein kinase, phospoinositide 3-kinase (PI3K/AKT), NF-kappa B and Wnt/beta-catenin. Intestinal PAK1 expression increases with inflammation and malignant transformation, although the biological relevance of PAKs in the development and progression of GI disease is only incompletely understood. This review highlights the importance of altered PAK activation within GI inflammation, emphasises its effect on oncogenic signalling and discusses PAKs as therapeutic targets of chemoprevention.

引用

页码：1173 / 1184

页数：12

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