Interleukin-33-cytokine of dual function or novel alarmin?

被引：267

作者：

Haraldsen, Guttorm ^{[1
,2
]}

Balogh, Johanna ^{[1
,2
]}

Pollheimer, Jurgen ^{[1
,2
]}

Sponheim, Jon ^{[2
,3
]}

Kuchler, Axel M. ^{[1
,2
]}

机构：

[1] Oslo Univ Hosp, Div Pathol, N-0027 Oslo, Norway

[2] Univ Oslo, Inst Pathol, N-0027 Oslo, Norway

[3] Asker & Baerum Hosp, Dept Internal Med, N-1351 Rud, Norway

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 05期

关键词：

UNCONVENTIONAL PROTEIN SECRETION; REGULATES CHROMATIN COMPACTION; RECEPTOR ACCESSORY PROTEIN; HUMAN ENDOTHELIAL-CELLS; N-TERMINAL PROPIECE; GROUP BOX-1 PROTEIN; IMMUNE-RESPONSES; HUMAN INTERLEUKIN-1-ALPHA; CUTTING EDGE; MAST-CELLS;

D O I：

10.1016/j.it.2009.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Cytokines are thought to exert biological effects through their specific cell surface membrane receptors but increasing evidence suggests that some also function within the nucleus. Here, we review current knowledge of such cytokines, including the novel interleukin (IL)-1 family member IL-33. Its extracellular function has attracted much recent attention as a ligand for the Th2-associated ST2 receptor, but the discoveries of its nuclear functions and modes of secretion are only just beginning to surface. We review the currently available data on IL-33 regulation, nuclear function and release and discuss them in the context of other intranuclear cytokines and the prototype alarmin HIMGB1, considering to what extent IL-33 can be seen as a novel member of the alarmin family.

引用

页码：227 / 233

页数：7

共 86 条

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