Pathogenesis of anaemia in hyperparathyroidism

被引：34

作者：

Sikole, A ^{[1
]}

机构：

[1] Univ Sv Kiril & Metodij, Dept Nephrol, Fac Med, Skopje 91000, Macedonia

来源：

MEDICAL HYPOTHESES | 2000年 / 54卷 / 02期

关键词：

D O I：

10.1054/mehy.1999.0027

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

It is suggested that parathyroid hormone (PTH), when in excessive amounts, interferes with normal erythropoiesis by downregulating the erythropoietin receptors on erythroid progenitor cells in the bone marrow. Therefore, physiologic concentrations of EPO can no longer sustain normal red cell counts, so normocytic and normochromic anaemia ensues. In primary hyperparathyroidism (HPT), this effect is observed with very high concentrations of PTH. In secondary HPT during chronic renal failure, this effect is more pronounced because erythropoietin synthesis is impaired. (C) 2000 Harcourt Publishers Ltd.

引用

页码：236 / 238

页数：3

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