Early-phase alcoholic liver disease: An update on animal models, pathology, and pathogenesis

被引:64
作者
Ramaiah, SK [1 ]
Rivera, C
Arteel, GE
机构
[1] Texas A&M Univ, Coll Vet Med, Dept Pathobiol, Texas Vet Med Ctr, College Stn, TX 77843 USA
[2] Baylor Coll Med, Dept Pediat, Sect Leukocyte Biol, Houston, TX 77030 USA
[3] Univ Louisville, Hlth Sci Ctr, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA
[4] Univ Louisville, Hlth Sci Ctr, James Graham Brown Canc Ctr, Louisville, KY 40292 USA
关键词
alcoholic hepatitis; alcoholic liver disease; animal models; cirrhosis; CYP2E1; endotoxin; fatty liver; fibrosis; Kupffer cells; Lieber-DeCarli liquid diet; LPS; neutrophils; osteopontin; steatohepatitis;
D O I
10.1080/10915810490502069
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Alcoholic liver disease (ALD) remains to be one of the most common etiology of liver disease and is a major cause of morbidity and mortality worldwide. The pathologic stages of ALD comprises of steatosis, steatohepatitis, and fibrosis/cirrhosis. Steatosis and steatohepatitis represents the early phase of ALD and are precursor stages for fibrosis/cirrhosis. Numerous research efforts have been directed at recognizing cofactors interacting with alcohol in the pathogenesis of steatosis and steatohepatitis. This review will elucidate the constellation of complex pathogenesis, available animal models, and microscopic pathologic findings mostly in the early-phase of ALD. The role of endotoxin, reactive oxygen species, alcohol metabolism, and cytokines are discussed. Understanding the mechanisms of early-phase ALD should provide insight into the development of therapeutic strategies and thereby decrease the morbidity and mortality associated with ALD.
引用
收藏
页码:217 / 231
页数:15
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