Sequence divergence in type III secretion gene clusters of the Burkholderia cepacia complex

被引：13

作者：

Glendinning, KJ ^{[1
]}

Parsons, YN ^{[1
]}

Duangsonk, K ^{[1
]}

Hales, A ^{[1
]}

Humphreys, D ^{[1
]}

Hart, CA ^{[1
]}

Winstanley, C ^{[1
]}

机构：

[1] Univ Liverpool, Dept Med Microbiol & Genitourinary Med, Liverpool L69 3GA, Merseyside, England

来源：

FEMS MICROBIOLOGY LETTERS | 2004年 / 235卷 / 02期

关键词：

Burkholderia cepacia complex; type III secretion; gene rearrangement;

D O I：

10.1016/j.femsle.2004.04.039

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Burkholderia cepacia complex (BCC) comprises a group of bacteria associated with opportunistic infections, especially in cystic fibrosis patients. B. cenocepacia J2315, of the transmissible ET12 lineage, contains a type III secretion (TTS) gene cluster implicated in pathogenicity. PCR and hybridisation assays indicate that the TTS gene cluster is present in all members of the BCC except B. cepacia (formerly genomovar I). The TTS gene clusters of B. cenocepacia J2315 and B. multivorans are similar in organisation but have variable levels of gene identity. Nucleotide sequence data obtained for the equivalent region of the B. cepacia genome indicate the absence of TTS structural genes due to a rearrangement likely to involve more than one step. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：229 / 235

页数：7

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