Bush Sophora Root polysaccharide and its sulfate can scavenge free radicals resulted from duck virus hepatitis

被引：23

作者：

Chen, Yun ^{[1
]}

Xiong, Wen ^{[1
]}

Zeng, Ling ^{[1
]}

Wang, Yu ^{[2
]}

Zhang, Shuaibing ^{[1
]}

Xu, Meiyun ^{[1
]}

Song, Meiyun ^{[1
]}

Wang, Yixuan ^{[1
]}

Du, Hongxu ^{[1
]}

Liu, Jiaguo ^{[1
]}

Wang, Deyun ^{[1
]}

Wu, Yi ^{[1
]}

Hu, Yuanliang ^{[1
]}

机构：

[1] Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing 210095, Jiangsu, Peoples R China

[2] BGI Shenzhen, Shenzhen 518083, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2014年 / 66卷

基金：

中国国家自然科学基金;

关键词：

Duck hepatitis A virus; Bush Sophora Root polysaccharide; Sulfated modification; Antioxidant; Hepatic injury; CHRONIC VIRAL-HEPATITIS; OXIDATIVE STRESS; NITRIC-OXIDE; ASPARTATE-AMINOTRANSFERASE; ALANINE AMINOTRANSFERASE; SUPEROXIDE-DISMUTASE; ALKALINE-PHOSPHATASE; ANTIOXIDANT STATUS; CHEMICAL BIOLOGY; OPTIMIZATION;

D O I：

10.1016/j.ijbiomac.2014.02.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In order to study the antioxidant effect of Bush Sophora Root polysaccharide (BSRPS) and its sulfate on anti-duck virus hepatitis (DVH), sulfated Bush Sophora Root polysaccharide (sBSRPS) was prepared by chlorosulfonic acid-pyridine method. Ducklings were fed with BSRPS and sBSRPS after challenged DHAV. Death was monitored, evaluation indexes of peroxidative and hepatic injury at the initial (4th and 8th hour) and later (54th hour) stages were detected. The results showed a fine treatment effect of BSRPS and sBSRPS. Visual hepatic pathological injury severities were less serious after the treatment At the initial stage, free radical levels in all groups were the same, and BSRPS and sBSRPS reduced the hepatic injury through inhibiting virus replication. At the later stage, mass free radicals were detected in VC group while free radical levels in BSRPS and sBSRPS groups were significantly lower than VC group. The antioxidant effect of BSRPS and sBSRPS might alleviate the hepatic injury. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：186 / 193

页数：8

共 49 条

[1]

Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine [J].