Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

被引：189

作者：

Baba, S

Osakabe, N

Natsume, M

Terao, J

机构：

[1] Meiji Seika Kaisha Ltd, Nutr Sci Ctr, Hlth & Biosci Labs, Sakado, Saitama 3500289, Japan

[2] Univ Tokushima, Sch Med, Dept Nutr, Tokushima 770, Japan

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2002年 / 33卷 / 01期

关键词：

procyanidin B2; (-)-epicatechin; absorption; urinary excretion; methylation; conjugation; degradation; antioxidant; rats; free radicals;

D O I：

10.1016/S0891-5849(02)00871-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats. After procyanidin 132 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions. (C) 2002 Elsevier Science Inc.

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页码：142 / 148

页数：7

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