The role of complement in neonatal hypoxic-ischemic cerebral injury

被引：12

作者：

Lassiter, HA ^{[1
]}

机构：

[1] Univ Louisville, Sch Med, Dept Pediat, Kosair Childrens Hosp Res Inst,Div Neonatal Med, Louisville, KY 40202 USA

[2] Univ Louisville, Sch Med, Dept Pediat, Kosair Childrens Hosp Res Inst,Neonatal Immunol R, Louisville, KY 40202 USA

来源：

CLINICS IN PERINATOLOGY | 2004年 / 31卷 / 01期

关键词：

D O I：

10.1016/j.clp.2004.03.005

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Complement activation participates in tissue injury after temporary loss of blood flow (ischemia-reperfusion injury). Recently reported evidence indicates that complement activation is a pathologic mechanism of injury in the post-hypoxic-ischemic neonatal brain. Therefore, recently developed complement inhibitors may find a role in the amelioration of neonatal hypoxic-ischemic cerebral injury. Further research is needed to better define the role of complement in human neonatal cerebral injury and to determine the neuroprotective effect and safety of pharmacologic agents designed to inhibit complement.

引用

页码：117 / +

页数：12

共 69 条

[1]

ADINOLFI M, 1983, REV PERINATAL MED, V5, P61

[2] Protective effect of C1 esterase inhibitor on reperfusion injury in the rat middle cerebral artery occlusion model [J].

Akita, N ;

Nakase, H ;

Kaido, T ;

Kanemoto, Y ;

Sakaki, T .

NEUROSURGERY, 2003, 52 (02) :395-400

[3]

BAKER PJ, 1977, J IMMUNOL, V118, P198

[4]

BERGER M, 1998, HUMAN COMPLEMENT SYS, P285

[5] Therapeutic potential of targeting the complement cascade in critical care medicine [J].

Bhole, D ;

Stahl, GL .

CRITICAL CARE MEDICINE, 2003, 31 (01) :S97-S104

[6] Kupffer cell-initiated remote hepatic injury following bilateral hindlimb ischemia is complement dependent [J].

Brock, RW ;

Nie, RG ;

Harris, KA ;

Potter, RF .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 280 (02) :G279-G284

[7]

COMPSTON DAS, 1991, ANN NY ACAD SCI, V633, P196

[8]

Cowell RM, 2003, J NEUROSCI, V23, P9459

[9] APPEARANCE OF IMMUNOGLOBULIN-G AND COMPLEMENT FACTOR C3 IN THE STRIATUM AFTER TRANSIENT FOCAL ISCHEMIA IN THE RAT [J].

CZURKO, A ;

NISHINO, H .

NEUROSCIENCE LETTERS, 1994, 166 (01) :51-54

[10] Neuroprotection by complement (C1) inhibitor in mouse transient brain ischemia [J].

De Simoni, MG ;

Storini, C ;

Barba, M ;

Catapano, L ;

Arabia, AM ;

Rossi, E ;

Bergamaschini, L .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (02) :232-239

← 1 2 3 4 5 6 7 →