Does information from axillary dissection change treatment in clinically node-negative patients with breast cancer? - An algorithm for assessment of impact of axillary dissection

Objective The authors assessed the impact of axillary dissection on adjuvant systemic therapy recommendations in patients with breast cancer. Summary Background Data With increasing use of systemic therapy in node-negative women and the desire to reduce treatment morbidity and cost, the need for axillary dissection in clinically node-negative patients with breast cancer has been challenged. Methods Two hundred eighty-two women with clinically negative axillae were analyzed using a model treatment algorithm. Systemic therapy was assigned with and without data from axillary dissection. Treatment shifts based on axillary dissection data were scored. Results Twenty-seven percent of clinically node-negative women had pathologically positive nodes. Eight percent of T1a and 10% of T1b tumors had positive nodes and would have been undertreated without axillary dissection. Seven percent of premenopausal women with tumors <1 cm and 13% with tumors greater than or equal to 1 cm had treatment changed by axillary dissection. For women 50 to 60 years of age, 10% with tumors <1 cm, 17% with tumors 1 to 2 cm with positive prognostic features, and 4% with poor prognostic features had significant treatment shifts after axillary dissection. For clinically node-negative women cider than 60 years of age not eligible for chemotherapy, only 3% of those with tumors <1 cm and none of those with tumors greater than or equal to 1 cm had their treatment changed by findings at axillary dissection. Treatment shifts based on axillary dissection were larger if the treatment algorithm allowed for more varied or more aggressive treatment options. Conclusions Data obtained from axillary dissection will alter adjuvant systemic therapy regimen in a significant number of clinically node-negative women younger than 60 years of age and for older women eligible to receive chemotherapy.