NKT cells: Potential targets for autoimmune disease therapy?

被引：64

作者：

Hammond, KJL

Godfrey, DI

机构：

[1] Monash Univ, Sch Med, Dept Pathol & Immunol, Prahran, Vic 3181, Australia

[2] La Jolla Inst Allergy & Immunol, Div Dev Immunol, San Diego, CA USA

来源：

TISSUE ANTIGENS | 2002年 / 59卷 / 05期

关键词：

autoimmunity; cytokines; NKT cells; T lymphocytes;

D O I：

10.1034/j.1399-0039.2002.590501.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

NKT cells represent a unique T cell lineage that recognize glycolipid antigens in the context of the non-classical MHC class I molecule CD1d. NKT cells are potent producers of immunoregulatory cytokines, and have been implicated in several different autoimmune diseases in mice and humans, including Type 1 diabetes, experimental autoimmune encephalomyelitis - a mouse model for multiple sclerosis, systemic lupus erythematosus, and scleroderma. This review will cover the evidence for an involvement for NKT cells in these autoimmune diseases, and discuss the potential for therapeutic manipulation of these cells as a means of preventing autoimmune disease in the clinic.

引用

页码：353 / 363

页数：11

共 70 条

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