Association of polymorphisms of dopamine D-2 receptor (DRD2), and dopamine transporter (DAT(1)) genes with schizoid/avoidant behaviors (SAB)

被引：88

作者：

Blum, K

Braverman, ER

Wu, S

Cull, JG

Chen, TJH

Gill, J

Wood, R

Eisenberg, A

Sherman, M

Davis, KR

Matthews, D

Fischer, L

Schnautz, N

Walsh, W

Pontius, AA

Zedar, M

Kaats, G

Comings, DE

机构：

[1] NYU,SCH MED,DEPT PSYCHIAT,NEW YORK,NY 10010

[2] CITY HOPE NATL MED CTR,DEPT MED GENET,DUARTE,CA 91010

[3] KANTROLL INC,SAN ANTONIO,TX 78209

[4] CHANG JUNG UNIV,TAINAN,TAIWAN

[5] UTHSC,DEPT COMP RESOURCES,SAN ANTONIO,TX

[6] UNIV N TEXAS,CTR HLTH SCI,DEPT PATHOL,DNA IDENT LAB,FT WORTH,TX 76107

[7] COMPREHENS NEUROBEHAV SYST,AUSTIN,TX 78246

[8] SAN MARCOS TREATMENT CTR,SAN MARCOS,TX 78667

[9] HLTH RES INST,PFEIFFER TREATMENT CTR,NAPERVILLE,IL 60563

[10] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02114

[11] HLTH & MED RES FDN,SAN ANTONIO,TX 78209

来源：

MOLECULAR PSYCHIATRY | 1997年 / 2卷 / 03期

关键词：

schizoid/avoidant behavior; polymorphisms; dopamine D-2 receptor gene (DRD2); dopamine transporter gene (DAT(1));

D O I：

10.1038/sj.mp.4000261

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The dopaminergic system, and in particular the dopamine D-2 receptor, has been implicated in reward mechanisms in the brain. Dysfunction of the D-2 dopamine receptors leads to aberrant substance-seeking behaviors (ethanol, drugs, tobacco, and food) and other related behaviors (pathological gambling, Tourette's disorder, attention-deficit/hyperactivity disorder). This is the first study supporting a strong association between the dopamine D-2 receptor Tag A(1) allele with schizoid/avoidant behavior (SAB). Additionally, an albeit weaker association between the 480-bp VNTR 10/10 allele of the dopamine transporter (DAT(1)) gene with SAB was similarly found.

引用

页码：239 / 246

页数：8

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