Timeline - The twentieth century struggle to decipher insulin signalling

被引：176

作者：

Cohen, Philip

机构：

[1] Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 11期

基金：

英国医学研究理事会;

关键词：

GLYCOGEN-SYNTHASE KINASE-3; RABBIT SKELETAL-MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR; ACTIVATED PROTEIN-KINASE; GLUCOSE-TRANSPORT; RECEPTOR SUBSTRATE-1; CRYSTAL-STRUCTURE; MOLECULAR-BASIS; ALPHA-ISOFORM; PHOSPHATASE;

D O I：

10.1038/nrm2043

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Following the discovery of insulin, it took the rest of the twentieth century to understand how this hormone regulates intracellular metabolism. What are the main discoveries that led to our current understanding of this process? And how is this new knowledge being exploited in an attempt to develop improved drugs to treat the epidemic of type-2 diabetes?.

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收藏

页码：867 / 873

页数：7

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